33th Kan-nichi Seminar
Date: 25 September, 2018
Time: 17:00-18:30
Venue: Special meeting room, G1 floor, Natural Science and Technology Library, Kakuma Campus, Kanazawa University

1. Prenatal and postnatal environmental chemical exposure and their associations with growth of children – brief introduction to mini-birth cohort in Jiangsu Province rural area

Zhijun Zhou

Professor and Chairman, Department of Occupational Health & Toxicology, School of Public Health, Fudan University


There is growing concern about the potential health effects of exposure to various environmental chemicals during pregnancy and infancy.
Evidence suggests that fetuses and children are more sensitive than adult to the toxicity of many environmental chemical pollutants because of their higher cell proliferation rates, lower immunologic competence, and decreased ability to detoxify carcinogens and to repair DNA damage.
We are conducting a prospective birth cohort study to examine the effects of prenatal exposure to these common toxicants on infant growth and early neurodevelopment. The study recruited 1312 mother-baby pairs delivered in Sheyang County, Jiangsu Province from June 2009 to January 2010. After that, we followed-up part of children under their parent’s informed consent at age 1, 2, 3, 6, 7, 8, 9 years old. The Maternal spot urine just before delivery, umbilical cord blood and meconium (only small part), children’s sport urine during interviewed time were collected except for the questionnaire interviewed related to demographic information, health behavior, environmental chemical exposure history. In the lab, the selected environmental chemicals or metabolites in the urine sample or umbilical blood were measured, such as pesticides, phthalates, phenols, heavy metals. The association of these chemicals with the children’s physical and mental growth was evaluated and potential adverse effects of environmental chemical exposure were discussed with several papers. More work and results are expected to come out.